General references

Greenwald, I. (2012) Notch and the awesome power of genetics. Genetics 191, 655-669. PMID: 22785620

In this essay, I highlight the indispensible role that genetic analysis played in the Notch field, from the identification of Notch mutants in Drosophila and C. elegans to the elucidation of the mechanism of signal transduction.

Greenwald, I. and Kovall, R. (2013) Notch signaling: genetics and structure. WormBook.

In this chapter for WormBook--a comprehensive resource for C. elegans research--we describe the core components, modulators and targets, as well as structural studies of conserved factors.

Selected recent publications

Attner, M.A., Keil, W., Benavidez, J.M. and Greenwald, I. HLH-2/E2A expression links stochastic and deterministic elements of a cell fate decision during C. elegans gonadogenesis. (2019) Curr Biol. PMID: 31402303

Tenen, C.C. and Greenwald, I. (2019) Cell non-autonomous function of daf-18/PTEN in the somatic gonad coordinates somatic gonad and germline development in C. elegans dauer larvae. Curr. Biol. PMID: 30827916

Langridge, P.D., Garcia-Diaz, A., Chan, J.Y. Greenwald, I. and Struhl, G. (2022). Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins Curr. Biol. PMID: 35349791

Shaffer, J.M. and Greenwald, I. (2022a) Floxed exon (Flexon): A flexibly positioned stop cassette for recombinase-mediated conditional gene expression. PNAS PMID: 35027456

Shaffer, J.M. and Greenwald, I. (2022b) SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo. Dev Cell PMID: 35413239

O'Keeffe, C. and Greenwald, I. (2022) EGFR signal transduction is downregulated in C. elegans vulval precursor cells during dauer diapause. Development PMID: 36227589

Complete list of publications:  https://www.ncbi.nlm.nih.gov/myncbi/iva.greenwald.1/bibliography/public/