General referencesGreenwald, I. (2012) Notch and the awesome power of genetics. Genetics 191, 655-669. PMID: 22785620
In this essay, I highlight the indispensible role that genetic analysis played in the Notch field, from the identification of Notch mutants in Drosophila and C. elegans to the elucidation of the mechanism of signal transduction.Greenwald, I. and Kovall, R. (2013) Notch signaling: genetics and structure. WormBook.
In this chapter for WormBook--a comprehensive resource for C. elegans research--we describe the core components, modulators and targets, as well as structural studies of conserved factors.
Selected recent publications
de la Cova, C., Townley, R., Regot, S.* and Greenwald, I.* (2017) A real-time biosensor for ERK activity reveals signaling dynamics during C. elegans cell fate specification. Dev Cell 42, 542-553. PMID: 28826819 Underwood, R.S., Deng, Y. and Greenwald, I. (2017) Integration of EGFR and LIN-12/Notch signaling by LIN-1/Elk1, the Cdk8 kinase module, and SUR-2/Med23 in Vulval Precursor Cell fate patterning in Caenorhabditis elegans. Genetics 207, 1473-1488. PMID: 28954762 Sallee, M.D.*, Littleford, H.E.* and Greenwald, I. (2017) A bhlh code for sexually dimorphic form and function of the C. elegans somatic gonad.Curr. Biol. 27, 1853-1860. PMID: 28602651Sallee, M.D. and Greenwald I. (2015) Dimerization-driven degradation of C. elegans and human E proteins. Genes & Development 13, 1356-1661. PMID: 26159995 Karp, X. and Greenwald, I. (2013) Control of cell fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent C. elegans. Proc. Natl. Acad. Sci. (USA), 110, 2181-2186. PMID: 23341633 de la Cova, C. and Greenwald, I. (2012) SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron Genes Dev. 26, 2524-2535. PMID: 23154983