IvaGreenwaldlab

General references

Greenwald, I. (2012) Notch and the awesome power of genetics. Genetics 191, 655-669. PMID: 22785620

In this essay, I highlight the indispensible role that genetic analysis played in the Notch field, from the identification of Notch mutants in Drosophila and C. elegans to the elucidation of the mechanism of signal transduction.

Greenwald, I. and Kovall, R. (2013) Notch signaling: genetics and structure. WormBook.

In this chapter for WormBook--a comprehensive resource for C. elegans research--we describe the core components, modulators and targets, as well as structural studies of conserved factors.

Selected recent publications

Sallee, M.D. and Greenwald I. (2015) Dimerization-driven degradation of C. elegans and human E proteins. Genes & Development 13, 1356-1661. PMID: 26159995 Shaye, D.D. and Greenwald I. (2015) The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons. Dev. Cell 32, 743-755. PMID: 25771894 Karp, X. and Greenwald, I. (2013) Control of cell fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent C. elegans. Proc. Natl. Acad. Sci. (USA), 110, 2181-2186. PMID: 23341633 de la Cova, C. and Greenwald, I. (2012) SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron Genes Dev. 26, 2524-2535. PMID: 23154983 Shaye, D.D. and Greenwald, I. (2011) OrthoList: a compendium of C. elegans genes with human orthologs. PLoS ONE 2011;6(5):e20085. doi:10.1371/journal.pone.0020085 PMID: 21647448