Greenwald, I. (2012) Notch and the awesome power of genetics.
Genetics 191, 655-669.
In this essay, I highlight the indispensible role that genetic analysis played in the
Notch field, from the identification of Notch mutants in Drosophila and C. elegans
to the elucidation of the mechanism of signal transduction.
Greenwald, I. and Kovall, R. (2013) Notch signaling: genetics and structure.
In this chapter for WormBook--a comprehensive resource for C. elegans
research--we describe the core components, modulators and targets, as well as
structural studies of conserved factors.
Selected recent publications
Sallee, M.D. and Greenwald I. (2015) Dimerization-driven degradation of C. elegans and human E proteins. Genes & Development 13, 1356-1661.
Shaye, D.D. and Greenwald I. (2015) The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons. Dev. Cell 32, 743-755.
Karp, X. and Greenwald, I. (2013) Control of cell fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent C. elegans. Proc. Natl. Acad. Sci. (USA), 110, 2181-2186.
de la Cova, C. and Greenwald, I. (2012) SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron Genes Dev. 26, 2524-2535.
Shaye, D.D. and Greenwald, I. (2011) OrthoList: a compendium of C. elegans genes with human orthologs. PLoS ONE 2011;6(5):e20085. doi:10.1371/journal.pone.0020085